Increasing cases of acute severe hepatitis of unknown origin were reported among young children in several regions and countries in Europe

the United States and Japan since Jan. 2022

causing widespread concern worldwide. Most of the infected patients were children under 16 years

with common manifestations of digestive symptoms

jaundice and elevated aminotransferase levels. Some patients deteriorated rapidly after the onset of the disease

requiring high clinical attention. For the purpose of identifying

diagnosing and treating the disease in a timely manner

and better responding to the outbreak of acute severe hepatitis of unknown origin in children

the recommendations are formulated by reviewing literature and consensus guidelines on children’s liver disease at home and abroad

and clinical practice.